CHAPTER II
REVIEW OF RELATED STUDIES AND LITERATURE
RELATED STUDIES
Oryan A., Naeini A. T., Nikahval B., and Gorjian E. (2009) Effect of Aqueous Extract of Aloe Vera on Experimental Cutaneous Wound Healing in Rat, Shiraz, Iran, Retrieved from http://vetarhiv.vef.unizg.hr/papers/2010-80-4-7.pdf,
According to the study of Oryan, Naeini, Nikahyal, and Gorjian, the extract of Aloe Vera can accelerate the healing process of cutaneous wounds of rats. Their study is similar to this experimental research because it used Aloe Vera extract to heal the cutaneous wounds. Instead of applying it to the cutaneous wounds of humans, they tried it to the cutaneous wounds of rats. The effects of their study, are the effects that the researchers are expecting in the end as well.
Christaki E. V., and Florou-Paneri P. C. (2010, April) Aloe Vera: A plant for many uses, Thessaloniki, Greece, Retrieved from https://www.researchgate.net/publication/265268175_Aloe_vera_A_plant_for_many_uses
In this study, it is stated that the Aloe Vera, the leaves to be exact, is divided into two: the latex, which is the bitter yellow liquid beneath the epidermis of the leaf, and the gel, which is the colorless and tasteless substance. It is connected in the researchers’ study because, according to them, the Aloe Vera can cure different types of skin conditions, because the plant contains wound healing, anti-inflammatory, immunity, anti-diabetic, anti-oxidant, anti-bacterial, anti-fungal, and anti-tumor. These are some of the benefits people can get from Aloe Vera.

Somboonwong, J. Thanamittramanee S., Jariyapongskul A., and Patumraj, S. (2000, April 1) Therapeutic Effects of Aloe Vera on Cutaneous Microcirculation and Wound Healing in Second Degree Burn Model in Rats, United States of America, Retrieved from https://europepmc.org/abstract/med/10808702/reload=0This article is connected to the researchers’ study because the Aloe Vera is used to cure wounds, particularly the burn wounds. The researchers of this study applied the gel, which is the extracts from the leaves of the Aloe Vera, on forty-eight wistar rats to see if the plant could heal second-degree burn. After fourteen days, the researchers finished observing and concluded that most of the burn wounds are healed because Aloe Vera showed that it has both anti-inflammation and wound healing promotion when applied on a second degree burn wound.

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Moisturizing effect of cosmetic formulations containing Aloe vera extract in different concentrations assessed by skin bioengineering techniques
Susi Elaine Dal’Belo, Lorena Rigo Gaspar and Patr?´cia Maria Berardo Gonc¸alves Maia Campos 2006 brazil https://pdfs.semanticscholar.org/aad3/107a764ba4f0209f0bb6efbb4705344dfea4.pdf(The polysaccharide-rich composition of Aloe vera extracts (Aloe barbadensis Miller), often used in cosmetic formulations, may impart moisturizing properties to the product. The aim of this study was to evaluate the effect of cosmetic formulations containing different concentrations of freeze-dried Aloe vera extract on skin hydration, after a single and a 1- and 2-week period of application, by using skin bioengineering techniques.)
RELATED LITERATURE
Sandhya, and Dr. Gowri. (2017) Effects of Aloe Vera on Skin and on Wound Healing – A Review, Chennai, Tamilnadu, Retrieved from https://www.ijsr.net/archive/v6i4/ART20172331.pdfIn the study of Sandhya and Dr. Gowri states that Aloe Vera is useful in treating wounds, burns, minor skin infections, cycts, diabetes, and many more. It is similar to the researchers’ experimental research since they used Aloe Vera to heal any minor skin infections, including cutaneous wounds, which is the goal of this research.
Leech, J. (2017, August 1). “What are the benefits of aloe vera?.” Medical News Today. Retrieved from https://www.medicalnewstoday.com/articles/318591.php.

This article is connected to the researchers’ experimental research because the Aloe Vera is used to cure wounds, but here, the wounds are burns. It is stated here that Aloe Vera is more effective if applied to the burn directly, instead of oral intake. This plant is the first herbal medicine to be approved by the Food and Drug Administration as an over-the-counter medicine for different types of wounds. It is also used as an ointment for faster healing process if applied to the wound.

Hashemi, S. A., Madani, S. A., and Abediankenari, S. (2015, May 19) The Review on Properties of Aloe Vera in Healing of Cutaneous Wounds, India, Maharashtra, Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452276/
In this article, it stated that Aloe Vera has useful effects on wounds especially in healing cutaneous wounds. Similar to the researchers’ experimental research, it studied the properties of Aloe Vera that can help to cure and accelerate the wound healing process.
Subramanian, S., Kumar, D. S., and Arulselvan P. (2006) Wound Healing Potential of Aloe Vera Leaf Gel Studied in Experimental Rabbits. Asian J. Biochem., 1: 178 – 185.

This article is connected to the researchers’ study because Aloe Vera is the plant they used for the treatment for the wound of experimental rabbit. The ointment created by the ethanolic extraction of the Aloe Vera is used to evaluate the healing process of the rabbit. The prevention effect shown by the ointment when applied to the wound supports the healing capabilities of the Aloe Vera.

Heggers, J. P., Pelley, R. P., and Robson, M. C. (1993) Beneficial Effects of Aloe in Wound Healing, Retrieved from https://doi.org/10.1002/ptr.2650070715(The therapeutic effects of Aloe vera have been examined in preventing progressive dermal ischaemia caused by burns, frostbite, electrical injury, distal dying flap and intra?arterial drug abuse. In vivo analysis of these injuries showed that the mediator of progressive tissue damage was thromboxane A2 (TxA2). Experimentally Aloe was compared to a variety of antithromboxane agents to include U38450, a lodoxamide, a lazaroid and Carrington wound gel. In the burn injury Aloe was comparable to the lodoxamide and lazaroid with an 82% to 85% tissue survival when compared with the control and the Carrington wound gel (p=0.05). Tissue survival in the experimental frostbite injury was 28.2% when compared with the control (p=0.05). Similar results were obtained for the electrical injury, and intra?arterial drug abuse. Clinically burn patients treated with Aloe healed without tissue loss as did those with frostbite (p=0.001). In the intra?arterial drug abuse patients Aloe reversed the tissue necrosis. This therapeutic approach was used to prevent progressive tissue loss in each injury by actively inhibiting the localized production of TxA2. Aloe not only acts as a TxA2 inhibitor but maintains a homeostasis within the vascular endothelium as well as the surrounding tissue.)
DEPENDENT VARIABLE RELATIONSHIP INDEPENDENT VARIABLE
Cutaneous Wounds of Human The extracts of Aloe Vera could be turned into a get that could cure cutaneous wounds when applied directly. This get can increase the wound’s healing process, at the same time, it can moisturize the wound and the surrounding skin. Thus, the wound will be protected from getting infected by the bacteria and will not leave any visible scars. Aloe Vera